Sebum Production Increased
During puberty sebum production is increased and the first flow of sebum through the previously empty duct might create shear forces of sufficient magnitude that pique the pilosebaseous gland. The body responds with the delivery of inflammatory molecules to propel cell division and quickly renovate the lining of the inner surface of the funnels. At the same time sebum at the external orifice of the sebaceous gland duct and/or the hair follicle leads to formation of a dry "plug" (comedone) which obstructs the flow of sebum. On exposure to oxygen, the comedone becomes dark forming what is usually referred to as a "blackhead". The water content of the comedone is lessened by evaporation and diffusion into the neighboring horny layer (keratin) of the surface epidermis forming a hardening of the comedone, commencing at the external surface. The comedone may become attached to the keratin and thus "moored" to adjacent elements of the skin. The comedone becomes modified chemically, as well as physically, thus turning out a material which is foreign to the body.

Inflammatory Response
This state of "outsiderness" aggravates a further inflammatory reaction, as well as immune reactions and other responses of various defense systems, particularly those associated with granulocytes and macrophages. Provided the inflammatory process and the immune and other defense responses are effective in eliminating or containing the effects of the comedone, further progression of acne manifestations do not occur. Regularly, however, the immune and other defense reactions are not effective in halting the acne process at this stage and the process progresses partly or wholly as described below.

Activity of the Sebaceous Glands
When the comedone is obstructing the outlet of the duct, the sebaceous glands can continue to form sebum, which accumulates in the sebum canal and in the glands, distending both. The distension and the resulting pressure lead to further intensification of the inflammatory response in the adjacent skin and subcutaneous tissues and create additional swelling (edema), redness (erythema), discomfort, and a mass, which includes the obstructed and thefore encysted sebaceous gland ("redhead", "pimple", or acne papule). Frequently, the defense mechanisms are not adequate to terminate this response promptly at the acne papule stage and it continues to progress as outlined below.

Growth of Acne Bacteria
The above conditions encourage the growth of bacteria, and the resultant infections involve the duct, the sebaceous glands and the surrounding tissues, usually in that order. The onset of the infection produces further inflammatory changes, thereby beginning a vicious cycle rendering continued and/or accentuated obstruction of the outflow of the sebum, which in turn leads to more pressure, more inflammation and continued or progressive infection. This leads to the formation of the acne pustule. The immune and other defense mechanisms having been defective to avoid these conditions from happening, frequently fail to arrest or reverse the course early in the acne pustule stage and it persists or advances additionally.

Clogging of Sebum Canals Leads to Acne Cysts
Obstruction amidst or without infection leads to the formation of cysts. Infection of a cyst results in the formation of an abscess which leads to local tissue destruction. If this destruction of tissue has involved the connective tissue elements of the skin or subcutaneous tissues to a large degree, healing is regularly accompanied and/or followed by scar formation.

Acne Scar Consequences
The scars in acne can vary from miniscule to major and severely disfiguring conditions which are permanent sequallae of acne. While the process by which acne arises and lasts for an indefinite time may and frequently does come to a halt as a result of treatment or spontaneously, the scars endure for life unless they are removed.

Acne Treatment
Acne scars can be prevented by treating acne inflammation in their early phase. When inflammation has not yet destroyed the tissue surrounding pimples, and before holes (ice-pick or pitted scarring), marks or bumps appear on your skin (raised, hyperthropic or even keloids). Old acne scars can also be diminished with the disciplined application twice a day every day for a few months of the anti-inflammatory, acne bacteria reducer and skin regenerating effects of GLYCOBALM.

The role of GLYCOBALM
GLYCOBALM™ acts as an exfoliant eliminating dead cells, destroys pathogens, heals and regenerates damaged tissue. It nourishes your skin and protects it from free radicals. Improves the skin's elasticity, and leaves it silky soft and soothed.

Once inside the follicle the bio-available compound in GLYCOBALM will stimulate the formation of new elastic cells, collagen and pigment, filling in scar cavities. It will also shrink and replace the old fibrous collagen formed to repair damaged tissues. Soon new 'invisible' hair, known as lanugo, will come through the restored hair follicles in those areas. It will also "pump" up the cells and the "ground substances" in the skin. That also reduces wrinkles on the surface of the skin.

The secret of GLYCOBALM™ is not only that it provides the normal ingredients which may be deficient in the skin, but also restores the skin renewal process by stimulating the germinal cells. The result is a healthier appearance of the skin with more thickness, a normal skin color, normal skin texture and normal skin tissue turgor.

What our customers say: "I have been using your product for 6 weeks and the inflammation on my face has considerably reduced. In addition, my pores are reducing in size and I have a cleaner, healthier feel to my face. Also it has cleared up my psoriasis! I have been fighting this disease with 80% success since my childhood (about 20 years) and never completely got rid of it. Until applying your cream for 3 weeks. THANK YOU - you don't know how good this makes me feel... "
Marc Sherry. Zurich. Switzerland.

GLYCOBALM for Acne Treatment
A gentle yet powerful solution for acne breakouts and even stubborn acne cysts that have not been amenable to other treatments

This acne cream yields what no other natural acne product does for recurrent stubborn acne and acne cysts because of the synergistic benefit of combining our biological serum with the most potent botanicals:

a) Inca Inchi Oil the richest vegetable oil in Omega-3 fatty acids. A powerful anti-inflammatory and with the ability to correct the deficit of linoleic acid in hair follicles which is a trigger of immoderate inflammatory reactions from our immune system. The oil is also a factor that reduces sebum output;

b) Helix Aspersa Müller Glycoconjugates, the miraculous serum, from a living creature with skin similar to human skin who never suffers from skin infections and acts as an effective adaptogen, anti-inflammatory, antioxidant, trigger of skin repair and skin regeneration, and enzyme dissolver of blocked pores;

c) Licorice Root Extract (*) an antimicrobial with potent activity against acne bacteria, anti-inflammatory, anti-irritant, antioxidant, and an inhibitor of sebum production;

d) Alpine Willow herb extract (Epilobium Fleischeri) a botanical source of keratolytic salicylic acid in a natural form, and an antimicrobial;

e) Essential oil from the roots of Coleus Forskohlii with strong antimicrobial activity and a strong medicinal smell that you might not appreciate for about 20 minutes until it fades away.

The smell is a small price you pay for an "essential" component of BIOSKINFORTE for it activates many of your more than 10 million olfactory receptor neurones. But its nothing = "nada" when compared to the value you get: the strongest remedy that effectively heals and contains acne breakouts without any side effects on your body or skin. You always have the choice to behave as if you were a warrior and just use the product without previously messing with your nose inside the jar.

f) Hyaluronic Acid a glycosaminoglycan (also present in the snail serum) that deeply moisturizes the skin and restores the capacity of the skin to hold in water;

g) An extract from the fruit of black pepper which enhances the penetration of the active ingredients.

Apply a little of this acne cream twice a day on all the area affected by acne cysts or stubborn pimples (whole face, chest or back).

Made in the USA. One Month Supply 50 grams = 1.76 oz

$69.98

(*) A New Dermatological Availability of the Flavonoid Fraction from Licorice Roots-Effect on Acne
Journal of Society Cosmetic Chemists Japan, VOL.37; NO.3; PAGE. 179-186(2003) Authors: Kambara Toshimitsua, Zhou Y, Kawashima Yoshihitoa, Kishida Naokoa, Mizutani Kenjia, Ikeda Takaoa, Kameyama Koichirob.

a) Research Center, Maruzen Pharmaceuticals Co., Ltd., 1089-8 Sagata, Shin-ichi, Fukuyama, 729-3102 Hiroshima, Japan. b) Aoyama Dermatological Clinic, dr@aoyamahihuka.com 5-1-3 Aoyama 8F Minato-ku Tokyo 107 Japan. Link: Licorice Roots-Effect on Acne

Abstract: Licochalcone-A, Polyol Soluble Licorice Extract P-U (now in the market as Licochalcone LR-15), prepared from the roots of Glycyrrhiza Inflata Batalin shows several activities such as inhibitory actions of testosterone 5 ALPHA-reductase, lipase and phospholipase A2, as well as androgen receptor antagonist, antimicrobial and SOD-like antioxidant actions, which relate to skin care, especially the suppression of acne formation and development. On basis of this evidence, a trial with acne patients was carried out and the efficacy of the extract was demonstrated clinically.