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Fibroblast Growth Factor Activity
Fibroblast growth factor (FGF) signaling is involved in a wide range of important biological activities with differential effects in various cell types. The activity of FGF is modulated by glycosaminoglycans, found both in the extracellular matrix and on the cell surface. They affect FGF signaling by interacting with both the growth factor and the FGF receptor.
These molecules are critical in wound healing as such dynamic process is interactive and depends on proper regulation of fibroblasts. Without regulation excessive scarring results as a feature of impaired healing (keloid and hypertrophic scars), a serious health problem that most of the time affects people's quality of life for the treatment cost of such lesions is high, and often, the results are unsatisfactory.
Fibroblast: a type of cell that synthesizes collagens, glycosaminoglycans, reticular and elastic fibers, and glycoproteins found in the extracellular matrix. In growing individuals fibroblasts are dividing and synthesizing ground substances.
The Helix Aspersa Müller Glycoconjugates Have Fibroblast Growth Factor Activity:
Facilitates the migration of keratinocytes, thus helping to repair wounds
Induces significant fibroblast proliferation
Enhances fibroblast functional capability, thus improving fibroplasias
Induces synthesis of new collagen
Provides hyaluronic acid (essential in all repair process)
The glycoconjugates help achieve the correct balance between the synthesis and degradation of important structural elements such as collagen and elastin
Collagenase: Enzymes that catalyze the hydrolysis of collagen and gelatin.
Gelatinase activity: A protease that begins the hydrolytic breakdown of proteins usually by splitting them into polypeptide chains. They are involved in early tissue repair and in prolonged tissue remodeling. Various types of matrix metalloproteinases (collagenase and gelatinase enzymes) are selectively expressed or activated at the various periods of wound healing and determine the presence or absence of abnormal scars: keloids or hypertrophic scars.
The matrix metalloproteinases (MMP) are a group of zinc-dependent enzymes , which degrade varying components of the extracellular skin matrix in both normal and diseased tissue. Skin matrix is a framework that holds the skin together and consists mainly of intermeshed polymers such as collagen and elastin. The skin matrix is responsible for the skin's mechanical properties, including firmness, strength, suppleness, and elasticity. The weaker and less regular the matrix, the more wrinkles, roughness, and sag one tends to have. Whenever skin is damaged, malformed or worn out, skin matrix is broken down by the MMP enzymes and then is synthesized by the fibroblasts. Therefore, MMP enzymes play a critical role in skin physiology.
The latest approach in skin care is to maintain a healthy balance of these enzymes.
In healthy, youthful skin, the synthesis and degradation of the matrix are in balance; damaged or redundant matrix is degraded while the deficit is replenished by the ongoing synthesis. Unfortunately, this intricate balance gets disrupted with age; too little of the matrix is synthesized and too much is degraded. MMP levels rise excessively with age. Research indicates that reversal of MMP levels to normal youthful levels in aged individuals is an effective method to remove the damaged matrix and preserve the healthy one. For this purpose, the utilization of MMP inhibitors in the form of drugs, cosmetic formulations, and lifestyle changes is the new cosmetic find.
Function of fibroblasts
The main function of fibroblasts is to maintain the structural integrity of connective tissue by continuously secreting precursors of the extracellular matrix. Fibroblasts secrete the precursors of all the components of the extracellular matrix, primarily the ground complex and a variety of fibers. The composition of the extracellular matrix determines the physical properties of connective tissues. Proteoglycans (proteins bound to glycosaminoglycans or glycoproteins) bind multiple components of the extracellular matrix by serving as important regulators of cell behavior. Tissue damage stimulates fibrocytes and induces migration and readily proliferation of fibroblasts in multiple stages of tissue repair including wound contraction. Fibroblasts can give rise to other cells, such as bone cells, fat cells, and smooth muscle cells. All those are cells of mesodermal origin, which means a layer from which the organs and tissues of the body develop through further differentiation.
Growth factors are polypeptides (proteins) that bind to receptors on the cell surface, with the primary result of activating cellular proliferation and/or differentiation. Many growth factors are quite versatile, stimulating cellular division in numerous different cell types; while others are specific to a particular cell-type. There are at least 21 distinct members of the FGF family of growth factors.
Fibroblast growth factors act specifically on various types of epithelial cells including keratinocytes of the skin, intestinal epithelial cells and hepatocytes. In addition, some types of Fibroblast Growth Factor have been shown to be more than growth factors: they can protect epithelial cells from damaging effects induced, for example, by radiation and oxidative stress. Therefore, they are currently in clinical trials for the treatment of oral mucositis, a severe side-effect of cancer therapy characterized by painful inflammation and ulceration of the oral epithelium. Reference: “Fibroblast growth factors in epithelial repair and cytoprotection”. Susanne Braun, Ulrich auf dem Keller, Heike Steiling and Sabine Werner Institute of Cell Biology, Department of Biology, ETH Zurich, Honggerberg, CH-8093 Zurich, Switzerland. April 2004.
Cartoon to illustrate the functions of FGFs in a healing skin wound. Upon lesions, dermal fibroblasts (violet) and __ T cells (red) secrete FGF-7 and FGF-10; suprabasal keratinocytes (green) express FGF-22. In a paracrine (blue and red arrows) or autocrine manner (green arrow), respectively, they activate keratinocytes at the wound edge and stimulate reepithelialization. In addition, they induce the expression of cytoprotective genes in keratinocytes, including the gene that encodes the Nrf2 transcription factor. Nrf2 then regulates the expression of proteins involved in the detoxification of ROS (Reactive Oxygen Species). The latter are produced in large amounts by neutrophils and macrophages as a defense against invading bacteria.
BIOSKINFORTE - Natural Acne Treatment Balm
A gentle yet powerful solution for acne breakouts and even stubborn acne cysts that have not been amenable to other treatments
This acne cream yields what no other natural acne product does for recurrent stubborn acne and acne cysts because of the synergistic benefit of combining our biological serum with the most potent botanicals:
a) Inca Inchi Oil the richest vegetable oil in Omega-3 fatty acids. A powerful anti-inflammatory and with the ability to correct the deficit of linoleic acid in hair follicles which is a trigger of immoderate inflammatory reactions from our immune system. The oil is also a factor that reduces sebum output;
b) Helix Aspersa Müller Glycoconjugates, the miraculous serum, from a living creature with skin similar to human skin who never suffers from skin infections and acts as an effective adaptogen, anti-inflammatory, antioxidant, trigger of skin repair and skin regeneration, and enzyme dissolver of blocked pores;
c) Licorice Root Extract (*) an antimicrobial with potent activity against acne bacteria, anti-inflammatory, anti-irritant, antioxidant, and an inhibitor of sebum production;
d) Alpine Willow herb extract (Epilobium Fleischeri) a botanical source of keratolytic salicylic acid in a natural form, and an antimicrobial;
e) Essential oil from the roots of Coleus Forskohlii with strong antimicrobial activity and a strong medicinal smell that you might not appreciate for about 20 minutes until it fades away.
The smell is a small price you pay for an "essential" component of BIOSKINFORTE for it activates many of your more than 10 million olfactory receptor neurones. But its nothing = "nada" when compared to the value you get: the strongest remedy that effectively heals and contains acne breakouts without any side effects on your body or skin. You always have the choice to behave as if you were a warrior and just use the product without previously messing with your nose inside the jar.
f) Hyaluronic Acid a glycosaminoglycan (also present in the snail serum) that deeply moisturizes the skin and restores the capacity of the skin to hold in water;
g) An extract from the fruit of black pepper which enhances the penetration of the active ingredients.
Apply a little of this acne cream twice a day on all the area affected by acne cysts or stubborn pimples (whole face, chest or back).
Made in the USA. One Month Supply 50 grams = 1.76 oz
$69.98
Natural Acne Gel, Rosacea Remedy & Scar Healing For Oily Skin
This gel is an oil free product and is a biological remedy for mild and moderate acne, rosacea, and scar healing with moisturizing seaweed extracts. Best for people with very oily skin conditions. All our products are safe for children, moms-to-be and breast fedding mothers.
Made in the USA. One Month's supply 50 grams = 1.76 oz
50 Grams in One Airless Pump Bottle: $59
Save at least 20% off
price & save on domestic or world wide shipping costs
when you order more than one month's supply
Discount Price Two Bottles: $47.20 each, at checkout within our secure shopping cart.
BIO ACNE CARE
Gentle but effective acne treatment serum for pimples & acne cysts, specially for those on the chest or back.
The product is oil free and contains the following ingredients that act in concert to yield benefits that go beyond the sum of those of their specific parts:
a) our biological Helix Aspersa Müller Glycoconjugates with antioxidant, antimicrobial & skin regeneration properties to heal skin lesions within the follicles, control acne bacteria and prevent and get rid of acne scars;
b) the active extract of the bark of the Black willow ( Salix Nigra) tree to enhance cell renewal on the surface of the skin, unclog pores and reduce acneic skin flora (Propionibacterium acnes and Staphylococcus aureus). The actual content of willow (Salix Nigra) extract expressed as standarized salicylic acid is less than 0.5%. The Salix Nigra extract also provides natural B-hydroxy acid activity, without the skin irritation commonly associated with synthetic salicylic acid;
c) modified glucomannan (carbohydrate) -high molecular weight heterpolysaccharides made up of glucose and mannose derived from the Japanese Konjac tuber (root)- that reduce the surface tension of oil and facilitates its dispersion into droplets. These droplets get distributed evenly along the skin’s surface, minimizing their presence and oily feel;
d) Hyaluronic Acid a glycosaminoglycan (also present in the snail serum) to deeply moisturize the skin and restore the capacity of the skin to hold in moisture; and seaweed extracts that provide moisture and trace minerals necessary for the recovery of damaged skin cells; and sodium salt of pyroglutamic acid (naturally in human skin) moisturizer;
e) Japanese Licochalcone LR-15 from Licorice (Glycyrrhiza inflate) extract which clinicals (*) in Japan have shown that at very low concentration reduces undesired p. acnes and other acneic skin flora, is anti-irritating, anti-inflammatory and reduces sebum output.
Apply a thin layer twice a day on all the area affected with acne (whole face, chest or back) and then always use sun protection. If you are allergic to salycilic acid or to aspirin do not use the product and if you experience stinging or irritation (very unlikely) you must stop using the product and consult your physician.
Made in the USA. One Month Supply 50 grams = 1.76 oz
50 Grams in Airless Pump Bottle.
Regular Price: $59
(*) A New Dermatological Availability of the Flavonoid Fraction from Licorice Roots-Effect on Acne
Journal of Society Cosmetic Chemists Japan, VOL.37; NO.3; PAGE. 179-186(2003) Authors: Kambara Toshimitsua, Zhou Y, Kawashima Yoshihitoa, Kishida Naokoa, Mizutani Kenjia, Ikeda Takaoa, Kameyama Koichirob.
a Research Center, Maruzen Pharmaceuticals Co., Ltd., 1089-8 Sagata, Shin-ichi, Fukuyama, 729-3102 Hiroshima, Japan. bAoyama Dermatological Clinic, dr@aoyamahihuka.com 5-1-3 Aoyama 8F Minato-ku Tokyo 107 Japan. Link: Licorice Roots-Effect on Acne
Abstract: Licochalcone-A, Polyol Soluble Licorice Extract P-U (now in the market as Licochalcone LR-15), prepared from the roots of Glycyrrhiza Inflata Batalin shows several activities such as inhibitory actions of testosterone 5 ALPHA-reductase, lipase and phospholipase A2, as well as androgen receptor antagonist, antimicrobial and SOD-like antioxidant actions, which relate to skin care, especially the suppression of acne formation and development. On basis of this evidence, a trial with acne patients was carried out and the efficacy of the extract was demonstrated clinically.
Ultra Exfoliate Your Skin with BIOSKINEXFOL
A home microdermabrasion cream with high quality micro-crystals, the same professionals use to breakdown hard, rough and old scar tissues, and allow for a deeper penetration of our exclusive all natural skin moisturizing and regeneration complex contained in the microdermabrasion cream. For ice-pick acne scars and for old and rough scars and actinic keratosis scales. Not for keloids.
Made in the USA. Two to Three Month's supply 120 grams = 4.23 oz
120 Gram Bottle: $89
Check also our specialty natural skin care products: BIO SKIN REJUVENATION CREAM to get rid of brown sun spots, and BIO STRETCH MARK CREAM for the prevention and treatment of new stretch marks.
Toll Free USA & Canada
BIOCUTIS skin treatment products
BIOSKINCARE 
A deeply moisturizing natural skin care balm that triggers the regeneration of damaged cells and replenishes the lipid barrier of the skin while preventing and removing scars from accidental injuries and post surgery; stretch marks; hypertrophic and keloid scars; keratois pilaris, actinic keratosis, dermatitis, psoriasis scales and all types of skin blemishes. 50 gram (1.76 oz) jar = $69.98 and for two or more 20% discount.
BIOSKINEXFOL™
A home microdermabrasion cream with high quality microcrystals, the same that professionals use to breakdown and polish away hard, rough and old scar tissues. Allows for a deeper penetration of our biological skin moisturizing and regeneration complex that is combined with the crystals in the microdermabrasion cream. 120 gram (4 oz) jar = $89
BIOSKINCLEAR™
Oil free moisturizing gel for acne, rosacea and facial scars, for people with very oily skin complexion. The product is based on the natural glycoconjugates compound produced by a little creature to function as its powerful immune modulator and skin regeneration trigger. Removes dead cells, unclogs sebum canals and dissolves scar tissues by enzymatic hydrolysis, without peeling. Promotes the secretion of antimicrobials on the skin surface that keep micro-organisms at bay and controls acne bacteria. Boosts the production of glycosaminoglycans, the molecules that hold in water in the dermis, thus truly moisturizing the skin from within. Communicates to your immune system that you are being taken care of and can moderate an otherwise extreme inflammatory reaction that may end up destroying healthy skin cells together with bacteria and sebum that has turned into a foreign matter. 50 gram (1.76 oz) airless pump bottle $59 and 20% off for two or more.
BIO SKIN REJUVENATION™
Same cream base with cell communicating ingredients and enzymes as in BIOSKINCARE to "digest" or dissolve blemishes, speed skin turnover, moisturize and tighten skin, plus two added ingredients: a natural pigment reducer and a human growth factor peptide, derived from the melanocyte-stimulating-hormone that blocks melanin synthesis, and inhibits the formation of unwanted pigmentation, allowing control over skin tone and brown spots. Leaves skin bright and refreshed! 50 gram (1.76 oz) jar = $79
BIO STRETCH MARK CREAM™
Helps to prevent pregnancy stretch marks, strengthen fragile skin, firm sagging breasts and body areas and reduce cellulite. It also works for newly formed stretch marks and scars, while BIOSKINEXFOL is recommended for old, rough and raised marks. This product is similar to BIOSKINCARE, although in a more economic container, with 4 oz. For use preferably on the body, not on the face, for it contains a higher concentration of the biological complex which results in an invisible film that retains in moisture by occluding the area where it is applied and could feel a little tacky on the face depending on how oily is your facial skin. 4 oz (120g) = $79.98
