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Copper Peptides
In the snail's body tissues, glycosaminoglycans (GAGs) are primarily located inside granules and in the shell, and are secreted onto the surface as a mucous material. Snail glycosaminoglycan tightly binds divalent copper cations (Cu 2+) and form copper peptides , with reportedly have skin regeneration properties. The concentration of copper in the snail secretions is notable, but copper peptides have been shown to be active in nanomolar amounts.
Copper-induced vascular endothelial growth factor expression and wound healing. Sen CK, Khanna S, Venojarvi M, Trikha P, Ellison EC, Hunt TK, Roy S. 2002 May;282(5):H1821-7. http://ajpheart.physiology.org/cgi/ingredient/full/282/5/H1821
Laboratory of Molecular Medicine, Department of Surgery, 512 Davis Heart & Lung Research Institute, The Ohio State University Medical Center, Columbus, Ohio 43210, USA.
Angiogenesis - the growth of new blood vessels - plays a central role in wound healing. Among many known growth factors, vascular endothelial growth factor (VEGF) is believed to be the most prevalent, efficacious, and long-term signal that is known to stimulate angiogenesis in wounds. Whereas a direct role of copper to facilitate angiogenesis has been evident two decades ago, the specific targets of copper action remained unclear. This report presents first evidence showing that inducible VEGF expression is sensitive to copper and that the angiogenic potential of copper may be harnessed to accelerate dermal wound contraction and closure. At physiologically relevant concentrations, copper sulfate induced VEGF expression in primary as well as transformed human keratinocytes. Copper shared some of the pathways utilized by hypoxia to regulate VEGF expression. Topical copper sulfate accelerated closure of excisional murine dermal wound allowed to heal by secondary intention. Copper-sensitive pathways regulate key mediators of wound healing such as angiogenesis and extracellular matrix remodeling. Copper-based therapeutics represents a feasible approach to promote dermal wound healing.
Certain types of copper peptide complexes possess both tissue protection and repair properties. Cu has protective and regenerative actions on several organ systems including skin, hair follicles, bone, gastric mucosa and intestinal linings. These types of copper complexes are increasingly used in cosmetic skin and hair care products and after dermatological skin renewal procedures, such as chemical peels, laser resurfacing and dermabrasion, to improve post-treatment skin recovery .
Aging reversal of skin
The greatest interest in copper peptides is in the area of reversing the effects of human ageing and ultraviolet damage on human skin. During ageing, skin becomes thinner and tends to accumulate various skin lesions and imperfections. The dermis and epidermis thin and the subcutaneous fat cells diminish in number.
A number of studies have found that the application of copper peptide creams to the human skin is more effective in promoting collagen development than retinoic acid or vitamin C. It also increase s the thickness of the epidermis and dermis, increases skin elasticity, reduces wrinkles and removes skin imperfections such as blotchiness and sun damage marks.
BIOSKINFORTE - Natural Acne Treatment Balm
A gentle yet powerful solution for acne breakouts and even stubborn acne cysts that have not been amenable to other treatments
This acne cream yields what no other natural acne product does for recurrent stubborn acne and acne cysts because of the synergistic benefit of combining our biological serum with the most potent botanicals:
a) Inca Inchi Oil the richest vegetable oil in Omega-3 fatty acids. A powerful anti-inflammatory and with the ability to correct the deficit of linoleic acid in hair follicles which is a trigger of immoderate inflammatory reactions from our immune system. The oil is also a factor that reduces sebum output;
b) Helix Aspersa Müller Glycoconjugates, the miraculous serum, from a living creature with skin similar to human skin who never suffers from skin infections and acts as an effective adaptogen, anti-inflammatory, antioxidant, trigger of skin repair and skin regeneration, and enzyme dissolver of blocked pores;
c) Licorice Root Extract (*) an antimicrobial with potent activity against acne bacteria, anti-inflammatory, anti-irritant, antioxidant, and an inhibitor of sebum production;
d) Alpine Willow herb extract (Epilobium Fleischeri) a botanical source of keratolytic salicylic acid in a natural form, and an antimicrobial;
e) Essential oil from the roots of Coleus Forskohlii with strong antimicrobial activity and a strong medicinal smell that you might not appreciate for about 20 minutes until it fades away.
The smell is a small price you pay for an "essential" component of BIOSKINFORTE for it activates many of your more than 10 million olfactory receptor neurones. But its nothing = "nada" when compared to the value you get: the strongest remedy that effectively heals and contains acne breakouts without any side effects on your body or skin. You always have the choice to behave as if you were a warrior and just use the product without previously messing with your nose inside the jar.
f) Hyaluronic Acid a glycosaminoglycan (also present in the snail serum) that deeply moisturizes the skin and restores the capacity of the skin to hold in water;
g) An extract from the fruit of black pepper which enhances the penetration of the active ingredients.
Apply a little of this acne cream twice a day on all the area affected by acne cysts or stubborn pimples (whole face, chest or back).
Made in the USA. One Month Supply 50 grams = 1.76 oz
$69.98
Natural Acne Gel, Rosacea Remedy & Scar Healing For Oily Skin
This gel is an oil free product and is a biological remedy for mild and moderate acne, rosacea, and scar healing with moisturizing seaweed extracts. Best for people with very oily skin conditions. All our products are safe for children, moms-to-be and breast fedding mothers.
Made in the USA. One Month's supply 50 grams = 1.76 oz
50 Grams in One Airless Pump Bottle: $59
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price & save on domestic or world wide shipping costs
when you order more than one month's supply
Discount Price Two Bottles: $47.20 each, at checkout within our secure shopping cart.
BIO ACNE CARE
Gentle but effective acne treatment serum for pimples & acne cysts, specially for those on the chest or back.
The product is oil free and contains the following ingredients that act in concert to yield benefits that go beyond the sum of those of their specific parts:
a) our biological Helix Aspersa Müller Glycoconjugates with antioxidant, antimicrobial & skin regeneration properties to heal skin lesions within the follicles, control acne bacteria and prevent and get rid of acne scars;
b) the active extract of the bark of the Black willow ( Salix Nigra) tree to enhance cell renewal on the surface of the skin, unclog pores and reduce acneic skin flora (Propionibacterium acnes and Staphylococcus aureus). The actual content of willow (Salix Nigra) extract expressed as standarized salicylic acid is less than 0.5%. The Salix Nigra extract also provides natural B-hydroxy acid activity, without the skin irritation commonly associated with synthetic salicylic acid;
c) modified glucomannan (carbohydrate) -high molecular weight heterpolysaccharides made up of glucose and mannose derived from the Japanese Konjac tuber (root)- that reduce the surface tension of oil and facilitates its dispersion into droplets. These droplets get distributed evenly along the skin’s surface, minimizing their presence and oily feel;
d) Hyaluronic Acid a glycosaminoglycan (also present in the snail serum) to deeply moisturize the skin and restore the capacity of the skin to hold in moisture; and seaweed extracts that provide moisture and trace minerals necessary for the recovery of damaged skin cells; and sodium salt of pyroglutamic acid (naturally in human skin) moisturizer;
e) Japanese Licochalcone LR-15 from Licorice (Glycyrrhiza inflate) extract which clinicals (*) in Japan have shown that at very low concentration reduces undesired p. acnes and other acneic skin flora, is anti-irritating, anti-inflammatory and reduces sebum output.
Apply a thin layer twice a day on all the area affected with acne (whole face, chest or back) and then always use sun protection. If you are allergic to salycilic acid or to aspirin do not use the product and if you experience stinging or irritation (very unlikely) you must stop using the product and consult your physician.
Made in the USA. One Month Supply 50 grams = 1.76 oz
50 Grams in Airless Pump Bottle.
Regular Price: $59
(*) A New Dermatological Availability of the Flavonoid Fraction from Licorice Roots-Effect on Acne
Journal of Society Cosmetic Chemists Japan, VOL.37; NO.3; PAGE. 179-186(2003) Authors: Kambara Toshimitsua, Zhou Y, Kawashima Yoshihitoa, Kishida Naokoa, Mizutani Kenjia, Ikeda Takaoa, Kameyama Koichirob.
a Research Center, Maruzen Pharmaceuticals Co., Ltd., 1089-8 Sagata, Shin-ichi, Fukuyama, 729-3102 Hiroshima, Japan. bAoyama Dermatological Clinic, dr@aoyamahihuka.com 5-1-3 Aoyama 8F Minato-ku Tokyo 107 Japan. Link: Licorice Roots-Effect on Acne
Abstract: Licochalcone-A, Polyol Soluble Licorice Extract P-U (now in the market as Licochalcone LR-15), prepared from the roots of Glycyrrhiza Inflata Batalin shows several activities such as inhibitory actions of testosterone 5 ALPHA-reductase, lipase and phospholipase A2, as well as androgen receptor antagonist, antimicrobial and SOD-like antioxidant actions, which relate to skin care, especially the suppression of acne formation and development. On basis of this evidence, a trial with acne patients was carried out and the efficacy of the extract was demonstrated clinically.
Ultra Exfoliate Your Skin with BIOSKINEXFOL
A home microdermabrasion cream with high quality micro-crystals, the same professionals use to breakdown hard, rough and old scar tissues, and allow for a deeper penetration of our exclusive all natural skin moisturizing and regeneration complex contained in the microdermabrasion cream. For ice-pick acne scars and for old and rough scars and actinic keratosis scales. Not for keloids.
Made in the USA. Two to Three Month's supply 120 grams = 4.23 oz
120 Gram Bottle: $89
Check also our specialty natural skin care products: BIO SKIN REJUVENATION CREAM to get rid of brown sun spots, and BIO STRETCH MARK CREAM for the prevention and treatment of new stretch marks.
Toll Free USA & Canada
BIOCUTIS skin treatment products
BIOSKINCARE 
A deeply moisturizing natural skin care balm that triggers the regeneration of damaged cells and replenishes the lipid barrier of the skin while preventing and removing scars from accidental injuries and post surgery; stretch marks; hypertrophic and keloid scars; keratois pilaris, actinic keratosis, dermatitis, psoriasis scales and all types of skin blemishes. 50 gram (1.76 oz) jar = $69.98 and for two or more 20% discount.
BIOSKINEXFOL™
A home microdermabrasion cream with high quality microcrystals, the same that professionals use to breakdown and polish away hard, rough and old scar tissues. Allows for a deeper penetration of our biological skin moisturizing and regeneration complex that is combined with the crystals in the microdermabrasion cream. 120 gram (4 oz) jar = $89
BIOSKINCLEAR™
Oil free moisturizing gel for acne, rosacea and facial scars, for people with very oily skin complexion. The product is based on the natural glycoconjugates compound produced by a little creature to function as its powerful immune modulator and skin regeneration trigger. Removes dead cells, unclogs sebum canals and dissolves scar tissues by enzymatic hydrolysis, without peeling. Promotes the secretion of antimicrobials on the skin surface that keep micro-organisms at bay and controls acne bacteria. Boosts the production of glycosaminoglycans, the molecules that hold in water in the dermis, thus truly moisturizing the skin from within. Communicates to your immune system that you are being taken care of and can moderate an otherwise extreme inflammatory reaction that may end up destroying healthy skin cells together with bacteria and sebum that has turned into a foreign matter. 50 gram (1.76 oz) airless pump bottle $59 and 20% off for two or more.
BIO SKIN REJUVENATION™
Same cream base with cell communicating ingredients and enzymes as in BIOSKINCARE to "digest" or dissolve blemishes, speed skin turnover, moisturize and tighten skin, plus two added ingredients: a natural pigment reducer and a human growth factor peptide, derived from the melanocyte-stimulating-hormone that blocks melanin synthesis, and inhibits the formation of unwanted pigmentation, allowing control over skin tone and brown spots. Leaves skin bright and refreshed! 50 gram (1.76 oz) jar = $79
BIO STRETCH MARK CREAM™
Helps to prevent pregnancy stretch marks, strengthen fragile skin, firm sagging breasts and body areas and reduce cellulite. It also works for newly formed stretch marks and scars, while BIOSKINEXFOL is recommended for old, rough and raised marks. This product is similar to BIOSKINCARE, although in a more economic container, with 4 oz. For use preferably on the body, not on the face, for it contains a higher concentration of the biological complex which results in an invisible film that retains in moisture by occluding the area where it is applied and could feel a little tacky on the face depending on how oily is your facial skin. 4 oz (120g) = $79.98
