A breakthrough biological acne treatment and scar removal product is now in the market: it is based on the ability of aminoacid chains called peptides to both a) destroy parasites, microbes, fungi and virus -without creating any bacterial resistance as pharmaceutical drugs do- and b) stimulate the regeneration of healthy skin cells whenever they are damaged. The biological active is produced by a cute little creature that lives in vineyards and backyards... the snail of the species Helix Aspersa. It is the mucin containing peptides that act by forming pores in microbial membranes or otherwise disrupting membrane integrity. The same peptides stimulate skin regeneration.

Land snails crawl over a variety of potentially contaminated surfaces and the snail foot is the primary site of entry for pathogens, parasites and a range of opportunistic organisms, so it is not much wonder they must have a defensive system to protect them. Such mechanism is the secretions they leave behind while crawling.

The mucus secreted on the body surfaces of mollusks is known to play crucial roles in locomotion, feeding, osmoregulation, reproduction and protection of epithelial surfaces.

The mucus from land snails contains acharan sulphate, a 29kDa glycosaminoglycan, present as a protein-free polysaccharide, and an antimicrobial protein that provides an immediate and rapid response to invading microorganisms.

Glycosaminoglycans (GAGs) are complex polysaccharides that participate in the regulation of physiological processes through the interactions with a wide variety of proteins. GAGs are primarily located inside granules in the snail's body tissues and in the shell, and are secreted onto the surface as a mucous material. Snail glycosaminoglycan tightly binds divalent copper cations and might form copper peptides, with reportedly have and are beeing synthezised and marketed for their skin regeneration properties.

The antimicrobial factor from the secretions of the Chilean snail has been known for years but scientists have focused on replicating it (by biosynthesis) in the laboratory. We have been the first to make the secretion available as it is, to clear skin infections directly and to repair damaged skin, in the form of a topical balm: GLYCOBALM.

The snail mucin exhibits high positive antibacterial activity both for the Gram-positive bacteria, Bacillus subtilis and Staphylococcus aureus and for the Gram-negative bacteria, Escherichia coli and Pseudomonas aeruginosa. The antimicrobial factor of the snail mucus was a glycoprotein whose molecular weight (MW) was about 160,000. It was composed of two subunits of MW 70,000-80,000. Comp Biochem Physiol C. 1985;82(2):345-8.

Antimicrobial peptides exist widely from bacteria to mammals. They are encoded by the genome and produced through regular processes of gene transcription. In addition to antibacterial, some peptides also have an effect on bacteria, fungi, viruses, and/or even cancer cells. It is believed that these cationic peptides interact directly with biological membranes without the need of a specific receptor. Although the mechanism of how these peptides kill cells is not clearly understood, antimicrobial peptides are considered to be promising alternative to overcome the growing antibiotic resistance problems.

The recent appearance of a growing number of bacteria resistant to conventional antibiotics has become a serious medical problem. To overcome this resistance, the development of antibiotics with novel mechanisms of action is a pressing issue.

In an increasing number of cases the use of what are called "classic" antibiotics is not sufficient for the treatment of infectious diseases. Many bacteria strains have built up resistance against the known classes of antibiotic and in the last thirty years no new classes of antibiotic have been discovered. There are few or no adequate agents against mycobacteria. And other micro-organisms, such as fungi, and determined parasites are also sometimes difficult to treat with existing antimicrobial agents. In view of the above, a new class of antimicrobial agents is highly desirable.

Endogenous antimicrobial peptides are exciting candidates as new antibacterial agents due to their broad antimicrobial spectra, highly selective toxicities, and the difficulty for bacteria to develop resistance to these peptides.

At present, two new types of antimicrobial agents are attracting the attention of pharmaceutical companies. On the one hand there are the carbohydrate-type agents. In addition, research is focussing on peptides, particularly (cationic) peptides, with antimicrobial activity. Cationic peptides contain a relatively large number of positively charged amino acids, such as arginine and lysine, and therefore carry a net positive charge, usually of at least +2, but often +4 or more. Antimicrobial peptides are an important component of the natural defence of most living organisms against infections. Many such antimicrobial peptides are cationic. In humans and other mammals such peptides, such as the defensins, are an important protein-like constituent of for instance neutrophil granulocytes. These cells are already involved at a very early stage in the defence against micro-organisms and in acute inflammation reactions. In addition, such peptides are also produced by many other cells, including epithelial cells, which are strategically located in relation to invading micro-organisms.

Glycosaminoglycans (GAGs)
The snail mucin also contains Glycosaminoglycans (GAGs) which are complex polysaccharides that participate in the regulation of physiological processes through the interactions with a wide variety of proteins.

GAGs, through their binding and regulation of a large number of ligands and receptors are important mediators of normal and tumor cell behavior, such as proliferation, differentiation, migration, and adhesion. The specific structure of GAG chains and their binding proteins  influence tumor cell proliferation, metastasis, and cancer progression.GAGs such as heparin, heparan sulfate, chondroitin sulfate, dermatan sulfate, and hyaluronic acid serve as key biological response modifiers by acting as (1) stabilizers, cofactors, and/or coreceptors for growth factors, cytokines, and chemokines; (2) regulators of enzyme activity; (3) signaling molecules in response to cellular damages, such as wound healing, infection, and tumorigenesis; and (4) targets for bacterial, viral, and parasitic virulence factors for attachment, invasion, and immune system.

Glycosaminoglycans exhibit tumor growth inhibitory activity, and fibroplast growth regulation, which may explain why the Helix Aspersa mucin is effective in the reduction of keloid scars.  

Treatments for Acne Scars
You can also use GLYCOBALM to prevent and repair acne scars.

Acne scars are caused by the body’s inflammatory response to acne lesions. The best way to prevent scars is to treat acne early, and as long as necessary. If scars form, GLYCOBALM is very effective in repairing acne scars by helping both to stimulate new skin cell formation when the skin has been damaged and to speed up the process of scar maturation.

The role of GLYCOBALM
GLYCOBALM™ destroys pathogens, acts as an exfoliant eliminating dead cells, heals and regenerates damaged tissue. It nourishes your skin and protects it from free radicals. Improves the skin's elasticity, and leaves it silky soft and soothed.

Once inside the follicle the bio-available compound in GLYCOBALM will stimulate the formation of new elastic cells, collagen and pigment, filling in scar cavities. It will also shrink and replace the old fibrous collagen formed to repair damaged tissues. Soon new 'invisible' hair, known as lanugo, will come through the restored hair follicles in those areas. It will also "pump" up the cells and the "ground substances" in the skin. That also reduces wrinkles on the surface of the skin.

The secret of GLYCOBALM™ is not only that it provides the normal ingredients which may be deficient in the skin, but also restores the skin renewal process by stimulating the germinal cells. The result is a healthier appearance of the skin with more thickness, a normal skin color, normal skin texture and normal skin tissue turgor.

What our customers say: "This cream is amazing. My skin has never been clearer. It seems to be working better than my prescription creams. My scars also appear to be reducing. I also have been using it on burns with excellent results. Thank you for such a wonderful product!"
Shelley Orton. UT. USA

GLYCOBALM for Acne Treatment
A gentle yet powerful solution for acne breakouts and even stubborn acne cysts that have not been amenable to other treatments

This acne cream yields what no other natural acne product does for recurrent stubborn acne and acne cysts because of the synergistic benefit of combining our biological serum with the most potent botanicals:

a) Inca Inchi Oil the richest vegetable oil in Omega-3 fatty acids. A powerful anti-inflammatory and with the ability to correct the deficit of linoleic acid in hair follicles which is a trigger of immoderate inflammatory reactions from our immune system. The oil is also a factor that reduces sebum output;

b) Helix Aspersa Müller Glycoconjugates, the miraculous serum, from a living creature with skin similar to human skin who never suffers from skin infections and acts as an effective adaptogen, anti-inflammatory, antioxidant, trigger of skin repair and skin regeneration, and enzyme dissolver of blocked pores;

c) Licorice Root Extract (*) an antimicrobial with potent activity against acne bacteria, anti-inflammatory, anti-irritant, antioxidant, and an inhibitor of sebum production;

d) Alpine Willow herb extract (Epilobium Fleischeri) a botanical source of keratolytic salicylic acid in a natural form, and an antimicrobial;

e) Essential oil from the roots of Coleus Forskohlii with strong antimicrobial activity and a strong medicinal smell that you might not appreciate for about 20 minutes until it fades away.

The smell is a small price you pay for an "essential" component of BIOSKINFORTE for it activates many of your more than 10 million olfactory receptor neurones. But its nothing = "nada" when compared to the value you get: the strongest remedy that effectively heals and contains acne breakouts without any side effects on your body or skin. You always have the choice to behave as if you were a warrior and just use the product without previously messing with your nose inside the jar.

f) Hyaluronic Acid a glycosaminoglycan (also present in the snail serum) that deeply moisturizes the skin and restores the capacity of the skin to hold in water;

g) An extract from the fruit of black pepper which enhances the penetration of the active ingredients.

Apply a little of this acne cream twice a day on all the area affected by acne cysts or stubborn pimples (whole face, chest or back).

Made in the USA. One Month Supply 50 grams = 1.76 oz

$69.98

(*) A New Dermatological Availability of the Flavonoid Fraction from Licorice Roots-Effect on Acne
Journal of Society Cosmetic Chemists Japan, VOL.37; NO.3; PAGE. 179-186(2003) Authors: Kambara Toshimitsua, Zhou Y, Kawashima Yoshihitoa, Kishida Naokoa, Mizutani Kenjia, Ikeda Takaoa, Kameyama Koichirob.

a) Research Center, Maruzen Pharmaceuticals Co., Ltd., 1089-8 Sagata, Shin-ichi, Fukuyama, 729-3102 Hiroshima, Japan. b) Aoyama Dermatological Clinic, dr@aoyamahihuka.com 5-1-3 Aoyama 8F Minato-ku Tokyo 107 Japan. Link: Licorice Roots-Effect on Acne

Abstract: Licochalcone-A, Polyol Soluble Licorice Extract P-U (now in the market as Licochalcone LR-15), prepared from the roots of Glycyrrhiza Inflata Batalin shows several activities such as inhibitory actions of testosterone 5 ALPHA-reductase, lipase and phospholipase A2, as well as androgen receptor antagonist, antimicrobial and SOD-like antioxidant actions, which relate to skin care, especially the suppression of acne formation and development. On basis of this evidence, a trial with acne patients was carried out and the efficacy of the extract was demonstrated clinically.